Distemper

Dog
Distemper
At least 3 doses, given between 6 and 16 weeks of age
2 doses, given 3-4 weeks apart
Puppies need a booster 1 year after completing their initial series, then all dogs need a booster every 3 years or more often.
Core dog vaccine. Caused by an airborne virus, distemper is a severe disease that, among other problems, may cause permanent brain damage.